New data reveals long-term benefit of adjuvant therapy for Stage III melanoma.
3 September 2020
Updated results published today in the prestigious New England Journal of Medicine herald the long-term effectiveness of a targeted combination drug therapy given after surgery in patients with high risk early melanoma.
The international study reports that in patients with Stage III BRAF-positive melanoma who were treated with adjuvant targeted therapy, there can be a long-lasting benefit from the treatment in preventing the disease from recurring.
In the Phase III trial, known as COMBI-AD, patients were treated with either a combination of a BRAF inhibitor (dabrafenib) and a MEK inhibitor (trametinib) or placebo given after surgery. The trial demonstrated early promising results after 12 months of treatment and significantly improved recurrence-free survival.
This latest publication revealed the effects of treatment have continued to be sustained after five years. In patients who received the combination therapy, 52% had no disease recurrence after five years. By comparison, only 36% of those patients on placebo – which was the standard of care at the time - had no disease recurrence during this time.
“Our research has demonstrated that many patients have long-term benefit on adjuvant combination targeted therapy, and it may be curative in most of those patients,” says co-senior author and Co-Medical Director of Melanoma Institute Australia Professor Georgina Long AO.
The study shows that adjvuant targeted therapy for patients with the BRAF mutation prevents recurrence in high-risk stage III melanoma.
“Melanoma Institute Australia is working closely with our international collaborators to take major steps forward in cancer treatment,” says Professor Long. “These results take us even closer to reaching our goal of zero deaths from melanoma this decade.”
Reinhard Dummer, M.D., Axel Hauschild, M.D.,Mario Santinami, M.D., Victoria Atkinson, M.D., Mario Mandalà, M.D., John M. Kirkwood, M.D., Vanna Chiarion Sileni, M.D., James Larkin, M.D., Ph.D., Marta Nyakas, M.D., Caroline Dutriaux, M.D., Andrew Haydon, M.B., B.S., Ph.D., Caroline Robert, M.D., Ph.D., Laurent Mortier, M.D., Ph.D., Jacob Schachter, .D., Thierry Lesimple, M.D., Ruth Plummer, M.D., Kohinoor Dasgupta, Ph.D., Eduard Gasal, M.D., Monique Tan, M.D., Georgina V. Long, M.B., B.S., Ph.D., and Dirk Schadendorf, M.D.
(2020) Five-Year Relapse-Free Survival With Adjuvant Dabrafenib Plus Trametinib in Stage III BRAF-Mutant Melanoma. NEJM.
Read online here.
It’s time again to say thank you to our amazing community fundraisers!
Videos of the sessions at the recent Patient Information Evening co-hosted by Melanoma Institute Australia (MIA) and Melanoma Patients Australia (MPA) are now available for viewing.
MIA is well-represented in the poster sessions at the Society for Melanoma Research 2019 Congress in the USA, with four poster presentations being given by members of our translational research lab.
Professor Georgina Long has today opened the Society for Melanoma Research 2019 Congress in Salt Lake City, Utah.
MIA’s Co-Medical Directors, Professor Georgina Long and Professor Richard Scolyer, have both been named Highly Cited Researchers, according to the Clarivate Analytics Highly Cited Researchers 2019 list.
Melanoma Patients Australia (MPA) and Melanoma Institute Australia (MIA) have announced a new multi-year agreement to provide enhanced support services for melanoma patients nationally.
It is time again to say thank you to our incredible community fundraisers who are helping us get closer to our goal of zero deaths from melanoma.
MIA has presented promising data regarding progression-free survival rates for advanced melanoma patients at the ESMO 2019 Congress in Barcelona.
Another month has flown by and yet again we have a host of amazing community fundraisers who generously gave up their time to help us reach our goal of zero deaths from melanoma.
Comments in favour of giving patients with BRAF-positive melanoma access to first-line immunotherapy need to be submitted online prior to October 9, 2019.
Jay's Longest Melanoma March documentary is screening this Sunday 22 September at 1pm (AEST) on Channel 10, capturing behind the scenes of the 2000km walk, Adelaide to Sydney in 50 days. Uniting to end melanoma.
It’s been a month since we highlighted some of our incredibly generous community fundraisers. We thought we’d have a look back at August and put the spotlight on more of the wonderful people who give up their time to fundraise for MIA, so we can continue to edge closer to our goal of zero deaths from melanoma.
They are a formidable team - in work and in play
This week, Melanoma Institute Australia hosted the first of six
Federal government urged
We want to thank every member of Team Melanoma and everyone who donated to them. With your help, we are moving closer to our goal of zero deaths from melanoma!
Lauren O'Brien tells us why she's running for a cause close to her heart
MIA could not do what we do without the incredible support and effort of our community fundraisers. We’d like to highlight some of the wonderful events organised by our community in