Research Publications

2021

For earlier research papers, prior to 2021, please email digital@melanoma.org.au.  

The efficacy of immunotherapy for in-transit metastases of melanoma: an analysis of randomized controlled trials

01 Apr 2021

Olofsson Bagge R, Ny L, Ascierto PA, Hodi FS, Larkin J, Robert C, Schachter J, Weber JS, Long GV, van Akkooi ACJ. Melanoma Res. (Epub 1 April 2021)

Preoperative Ultrasound Assessment of Regional Lymph Nodes in Melanoma Patients Does not Provide Reliable Nodal Staging: Results From a Large Multicentre Trial

01 Apr 2021

Thompson JF, Haydu LE, Uren RF, Andtbacka RH, Zager JS, Beitsch PD, Agnese DM, Mozzillo N, Testori A, Bowles TL, Hoekstra HJ, Kelley MC, Sussman J, Schneebaum S, Smithers BM, McKinnon G, Hsueh E, Jacobs L, Schultz E, Reintgen D, Kane JM, Friedman EB, Wang H, Van Kreuningen L, Schiller V, Elashoff DA, Elashoff R, Cochran AJ, Stern S, Faries MB; MSLT-II Trial Group. Ann Surg. (Epub 1 April 2021)

A combination of epigenetic BET and CDK9 inhibitors for treatment of human melanoma

26 Mar 2021

Al Emran A, Tseng HY, Gunatilake D, Cook SJ, Ahmed F, Wang S, Hersey P, Gallagher SJ, Tiffen JC. J Invest Dermatol. (Epub 26 March 2021)

Should I Have Adjuvant Immunotherapy? An Interview Study Among Adults with Resected Stage 3 Melanoma and Their Partners

24 Mar 2021

Livingstone A, Milne D, Dempsey K, Muscat DM, Menzies AM, Howard K, Stockler MR, Morton RL. Patient. (Epub 24 March 2021)

Immunotherapy use outside clinical trial populations: never say never?

23 Mar 2021

Rzeniewicz K, Larkin J, Menzies AM, Turajlic S. Ann Oncol. (Epub 23 March 2021)

Novel adjuvant options for cutaneous melanoma

23 Mar 2021

Dimitriou F, Long GV, Menzies AM. Ann Oncol. (Epub 23 March 2021)

Treatment of in-transit melanoma metastases using intralesional PV-10

18 Mar 2021

Thompson JF, Saw RPM, Dalton JM, Stretch JR, Spillane AJ, Osborne NS, Williams GJ, Lo SN. Melanoma Res. (Epub 18 March 2021)

Recent advancements in melanoma management

18 Mar 2021

Krishnan T, Menzies AM, Roberts-Thomson R. Intern Med J. (Epub 18 March 2021)

Pathological response and tumour bed histopathological features correlate with survival following neoadjuvant immunotherapy in stage III melanoma

17 Mar 2021

Rawson RV, Adhikari C, Bierman C, Lo S, Shklovskaya E, Rozeman EA, Menzies AM, van Akkooi ACJ, Shannon KF, Gonzalez M M, Guminski AD, Tetzlaff MT, Stretch JR, Eriksson H, van Thienen JV, Wouters MW, Haanen JBAG, Klop WMC, Zuur CL, van Houdt WJ, Nieweg OE, Ch'ng S, Rizos H, Saw RPM, Spillane AJ, Wilmott JS, Blank CU, Long GV, van de Wiel BA, Scolyer RA. Ann Oncol. (Epub 17 March 2021)

Longitudinal melanonychia striata mimicking a melanoma during pregnancy

17 Mar 2021

Martin A, Ribero S, Martin LK, Guitera P. Australas J Dermatol. (Epub 17 March 2021)

Feasibility of modifying the hospital environment to reduce the length of amnesia after traumatic brain injury: a pilot randomized controlled trial

16 Mar 2021

Lannin NA, Galea C, Coulter M, Gruen R, Jolliffe L, Ownsworth T, Schmidt J, Unsworth C. Int J Qual Health Care. (Epub 16 March 2021)

Outcome of melanoma patients with elevated LDH treated with first-line targeted therapy or PD-1-based immune checkpoint inhibition

15 Mar 2021

Knispel S, Gassenmaier M, Menzies AM, Loquai C, Johnson DB, Franklin C, Gutzmer R, Hassel JC, Weishaupt C, Eigentler T, Schilling B, Schummer P, Sirokay J, Kiecker F, Owen CN, Fleischer MI, Cann C, Kähler KC, Mohr P, Bluhm L, Niebel D, Thoms KM, Goldinger SM, Reinhardt L, Meier F, Berking C, Reinhard R, Susok L, Ascierto PA, Drexler K, Pföhler C, Tietze J, Heinzerling L, Livingstone E, Ugurel S, Long GV, Stang A, Schadendorf D, Zimmer L. Eur J Cancer. (Epub 15 March 2021)

Neoadjuvant ipilimumab plus nivolumab in synchronous clinical stage III melanoma

15 Mar 2021

Versluis JM, Reijers ILM, Rozeman EA, Menzies AM, van Akkooi ACJ, Wouters MW, Ch'ng S, Saw RPM, Scolyer RA, van de Wiel BA, Schilling B, Long GV, Blank CU. Eur J Cancer. (Epub 15 March 2021)

Organ transplantation and outcomes in patients with a past history of melanoma: a systematic review and meta-analysis

15 Mar 2021

Williams GJ, Webster AC, Thompson JF. Clin Transplant. (Epub 15 March 2021)

Validated specialty-specific models for multi-disciplinary microsurgery training laboratories: a systematic review

15 Mar 2021

Crouch G, Wong G, Hong J, Varey A, Haddad R, Wang ZZ, Wykes J, Koutalistras N, Clark JR, Solomon M, Bannon P, McBride KE, Ch'ng S. ANZ J Surg. (Epub 15 March 2021)

γδ T cells in Merkel cell carcinomas have a proinflammatory profile prognostic of patient survival

05 Mar 2021

Gherardin NA, Waldeck K, Caneborg A, Martelotto LG, Balachander S, Zethoven M, Petrone PM, Pattison A, Wilmott JS, Quiñones-Parra SM, Rossello F, Posner A, Wong A, Weppler AM, Shannon KF, Hong A, Ferguson PM, Jakrot V, Raleigh J, Hatzimihalis A, Neeson PJ, Deleso P, Johnston M, Chua M, Becker JC, Sandhu S, McArthur GA, Gill AJ, Scolyer RA, Hicks RJ, Godfrey DI, Tothill RW. Cancer Immunol Res. (Epub 5 Mar 2021)

To be mortal is human: professional consensus around the need for more psychology in palliative care

04 Mar 2021

Sansom-Daly UM, Lobb EA, Evans HE, Breen LJ, Ugalde A, Best M, Zomerdijk N, Beasley EA, Taylor KL, Clayton J, Sharpe L, Bartula I, Olver I; PoCoG End of Life Care Special Interest Group. BMJ Support Palliat Care. (Epub 4 Mar 2021)

Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling.

04 Mar 2021

Vergara IA, Mintoff CP, Sandhu S, McIntosh L, Young RJ, Wong SQ, Colebatch A, Cameron DL, Kwon JL, Wolfe R, Peng A, Ellul J, Dou X, Fedele C, Boyle S, Arnau GM, Raleigh J, Hatzimihalis A, Szeto P, Mooi J, Widmer DS, Cheng PF, Amann V, Dummer R, Hayward N, Wilmott J, Scolyer RA, Cho RJ, Bowtell D, Thorne H, Alsop K, Cordner S, Woodford N, Leditschke J, O'Brien P, Dawson SJ, McArthur GA, Mann GJ, Levesque MP, Papenfuss AT, Shackleton M. Nat Commun. (Epub 4 Mar 2021)

Predicting sentinel node positivity in melanoma patients: external validation of a risk-prediction calculator (the MIA nomogram) using a large European population-based patient cohort

03 Mar 2021

El Sharouni MA, Varey AHR, Witkamp AJ, Ahmed T, Sigurdsson V, van Diest PJ, Scolyer RA, Thompson JF, Lo SN, van Gils CH. Br J Dermatol. (Epub 3 March 2021)

Surgical excision margins in primary cutaneous melanoma: A systematic review and meta-analysis

03 Mar 2021

Hanna S, Lo SN, Saw RP. Eur J Surg Oncol. (Epub 3 March 2021)

Efficiency of Detecting New Primary Melanoma Among Individuals Treated in a High-risk Clinic for Skin Surveillance.

01 Mar 2021

Guitera P, Menzies SW, Coates E, Azzi A, Fernandez-Penas P, Lilleyman A, Badcock C, Schmid H, Watts CG, Collgros H, Liu R, van Kemenade C, Mann GJ, Cust AE. JAMA Dermatol. (Epub 1 March 2021)

 

Technological (R)Evolution Leads to Detection of More Sentinel Nodes in Patients with Melanoma in the Head and Neck Region

26 Feb 2021

Berger D, van den Berg N, van der Noort V, van der Hiel B, Valdés Olmos RA, Buckle TA, KleinJan G, Brouwer OR, Vermeeren L, Karakullukçu B, van den Brekel M, van der Wiel B, Nieweg OE, Balm A, van Leeuwen FE, Klop M. J Nucl Med. (Epub Feb 26 2021)

Estimating the potential impact of interventions to reduce over-calling and under-calling of melanoma

25 Feb 2021

Gibson M, Scolyer RA, Soyer HP, Ferguson P, McGeechan K, Irwig L, Bell K.

J Eur Acad Dermatol Venereol. (Epub 25 Feb 2021)

Tumour gene expression signature in primary melanoma predicts long-term outcomes

18 Feb 2021

Garg M, Couturier DL, Nsengimana J, Fonseca NA, Wongchenko M, Yan Y, Lauss M, Jönsson GB, Newton-Bishop J, Parkinson C, Middleton MR, Bishop DT, McDonald S, Stefanos N, Tadross J, Vergara IA, Lo S, Newell F, Wilmott JS, Thompson JF, Long GV, Scolyer RA, Corrie P, Adams DJ, Brazma A, Rabbie R. Nat Commun. 2021 Feb 18;12(1):1137

Development and Validation of Nomograms to Predict Local, Regional, and Distant Recurrence in Patients With Thin (T1) Melanomas

18 Feb 2021

El Sharouni MA, Ahmed T, Varey AHR, Elias SG, Witkamp AJ, Sigurdsson V, Suijkerbuijk KPM, van Diest PJ, Scolyer RA, van Gils CH, Thompson JF, Blokx WAM, Lo SN. J Clin Oncol. (Epub Feb 18 2021)

The efficacy of immunotherapy for in-transit metastases of melanoma: an analysis of randomized controlled trials

18 Feb 2021

Olofsson Bagge R, Ny L, Ascierto PA, Hodi FS, Larkin J, Robert C, Schachter J, Weber JS, Long GV, van Akkooi ACJ. Melanoma Res. (Epub 18 Feb 2021)

School-based interventions to improve sun-safe knowledge, attitudes and behaviors in childhood and adolescence: A systematic review.

17 Feb 2021

Reyes-Marcelino G, Wang R, Gultekin S, Humphreys L, Smit AK, Sharman AR, St Laurent AG, Evaquarta R, Dobbinson SJ, Cust AE. Prev Med. (Epub Feb 17 2021)

G9a inhibition enhances checkpoint inhibitor blockade response in melanoma.

15 Feb 2021

Kelly G, Al-Ejeh F, McCuaig RD, Casciello F, Kamal N, Ferguson B, Pritchard AL, Ali S, Silva I, Wilmott JS, Long GV, Scolyer RA, Rao S, Hayward NK, Gannon F, Lee JS. Clin Cancer Res. (Epub Feb 15 2021)

Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib: a clinical validation study.

12 Feb 2021

Syeda MM, Wiggins JM, Corless BC, Long GV, Flaherty KT, Schadendorf D, Nathan PD, Robert C, Ribas A, Davies MA, Grob JJ, Gasal E, Squires M, Marker M, Garrett J, Brase JC, Polsky D.Lancet Oncol. (Epub Feb 12 2021)

Implementation of patient-reported outcome measures and patient-reported experience measures in melanoma clinical quality registries: a systematic review..

11 Feb 2021

Blood Z, Tran A, Caleo L, Saw R, Dieng M, Shackleton M, Soyer HP, Arnold C, Mann GJ, Morton RL. BMJ Open. 2021 Feb 11;11(2):e040751

Targeting the Microbiome to Overcome Resistance

08 Feb 2021

Simpson RC, Shanahan E, Scolyer RA, Long GV. Cancer Cell. 2021 Feb 8;39(2):151-153

Survival and biomarker analyses from the OpACIN-neo and OpACIN neoadjuvant immunotherapy trials in stage III melanoma

08 Feb 2021

Rozeman EA, Hoefsmit EP, Reijers ILM, Saw RPM, Versluis JM, Krijgsman O, Dimitriadis P, Sikorska K, van de Wiel BA, Eriksson H, Gonzalez M, Torres Acosta A, Grijpink-Ongering LG, Shannon K, Haanen JBAG, Stretch J, Ch'ng S, Nieweg OE, Mallo HA, Adriaansz S, Kerkhoven RM, Cornelissen S, Broeks A, Klop WMC, Zuur CL, van Houdt WJ, Peeper DS, Spillane AJ, van Akkooi ACJ, Scolyer RA, Schumacher TNM, Menzies AM, Long GV, Blank CU. Nat Med. (Epub Feb 8 2021)

Pathological response and survival with neoadjuvant therapy in melanoma: a pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC)

08 Feb 2021

Alexander M. Menzies, Rodabe N. Amaria, Elisa A. Rozeman, Alexander C. Huang, Michael T. Tetzlaff, Bart A. van de Wiel, Serigne Lo, Ahmad A. Tarhini, Elizabeth M. Burton, Thomas E. Pennington, Robyn P. M. Saw, Xiaowei Xu, Giorgos C. Karakousis, Paolo A. Ascierto, Andrew J. Spillane, Alexander C. J. van Akkooi, Michael A. Davies, Tara C. Mitchell, Hussein A. Tawbi, Richard A. Scolyer, Jennifer A. Wargo, Christian U. Blank & Georgina V. Long. Nat Med (2021). 

Desmoplastic Melanoma: A review of its pathology and clinical behaviour, and of management recommendations in published guidelines

05 Feb 2021

Hughes TM, Williams GJ, Gyorki DE, Kelly JW, Stretch JR, Varey AHR, Hong AM, Scolyer RA, Thompson JF. J Eur Acad Dermatol Venereol. (Epub Feb 5 2021)

A patient-centric dataset of images and metadata for identifying melanomas using clinical context.

28 Jan 2021

Rotemberg V, Kurtansky N, Betz-Stablein B, Caffery L, Chousakos E, Codella N, Combalia M, Dusza S, Guitera P, Gutman D, Halpern A, Helba B, Kittler H, Kose K, Langer S, Lioprys K, Malvehy J, Musthaq S, Nanda J, Reiter O, Shih G, Stratigos A, Tschandl P, Weber J, Soyer HP.   Scientific Data. 2021 Jan 28;8(1):34.

Lentiginous melanoma (lentigo maligna and lentigo maligna melanoma) in Australia: clinicopathological characteristics, management and recurrence rates after 10 years follow-up at a tertiary centre.

27 Jan 2021

Collgros H, Rodriguez-Lomba E, Regio Pereira A, Lo SN, Scolyer RA, Guitera P.  The Journal of the European Academy of Dermatology and Venereology. (Epub Jan 27 2021)

 

Reply to E. Hindié.

25 Jan 2021

Eggermont AMM, Blank CU, Mandala M, Long GV, Atkinson VG, Dalle S, Haydon AM, Meshcheryakov A, Khattak A, Carlino MS, Sandhu S, Larkin J, Puig S, Ascierto PA, Rutkowski P, Schadendorf D, Koornstra R, Hernandez-Aya L, Di Giacomo AM, van den Eertwegh AJM, Grob JJ, Gutzmer R, Jamal R, Lorigan PC, van Akkooi ACJ, Krepler C, Ibrahim N, Marreaud S, Kicinski M, Suciu S, Robert C.  Journal Clinical Oncology. (Epub Jan 25 2021).

 

Clinical impact of COVID-19 on patients with cancer treated with immune checkpoint inhibition.

19 Jan 2021

Rogiers A, Pires da Silva I, Tentori C, Tondini CA, Grimes JM, Trager MH, Nahm S, Zubiri L, Manos M, Bowling P, Elkrief A, Papneja N, Vitale MG, Rose AAN, Borgers JSW, Roy S, Mangana J, Pimentel Muniz T, Cooksley T, Lupu J, Vaisman A, Saibil SD, Butler MO, Menzies AM, Carlino MS, Erdmann M, Berking C, Zimmer L, Schadendorf D, Pala L, Queirolo P, Posch C, Hauschild A, Dummer R, Haanen J, Blank CU, Robert C, Sullivan RJ, Ascierto PA, Miller WH, Jr., Stephen Hodi F, Suijkerbuijk KPM, Reynolds KL, Rahma OE, Lorigan PC, Carvajal RD, Lo S, Mandala M, Long GV.  J Immunother Cancer ;9:e001931 (Epub Jan 2021)

 

Sex bias of females in survival from cancer and infections. Is X the answer?

19 Jan 2021

Emran AA, Gallagher SJ, Tiffen JC, Hersey P. Br J Cancer. (Epub Jan 19 2021)

Genetic drivers of non-cutaneous melanomas: challenges and opportunities in a heterogeneous landscape.

17 Jan 2021

Vergara IA, Wilmott JS, Long GV, Scolyer RA.  Exp Dermatol (Epub Jan 17 2021).

 

A multicenter study of nevus-associated melanoma versus de novo melanoma, tumor thickness and body site differences.

16 Jan 2021

Dessinioti C, Geller AC, Stergiopoulou A, Dimou N, Lo S, Keim U, Gershenwald JE, Haydu LE, Dummer R, Mangana J, Hauschild A, Egberts F, Vieira R, Brinca A, Zalaudek I, Deinlein T, Evangelou E, Thompson JF, Scolyer RA, Peris K, Garbe C, authors). SAecs.  British Journal of Dermatology (Epub Jan 16 2021).

 

Performance of Long-Term CT and PET/CT Surveillance for Detection of Distant Recurrence in Patients with Resected Stage IIIA-D Melanoma.

03 Jan 2021

Turner RM, Dieng M, Khanna N, Nguyen M, Zeng J, Nijhuis AAG, Nieweg OE, Einstein AJ, Emmett L, Lord SJ, Menzies AM, Thompson JF, Saw RPM, Morton RL.  Ann Surg Oncol. (Epub Jan 3 2021).

 

ASO Author Reflections: Longitudinal Diagnostic Accuracy of Surveillance Imaging in Resected Stage III Melanoma Patients.

02 Jan 2021

Dieng M, Morton RL.  Annals of Surgical Oncology (Epub Jan 2 2021).

 

Restricted Mean Survival Time and Cure-Rate Modeling in Estimating Relapse-Free Survival Benefit With Adjuvant Dabrafenib + Trametinib Treatment in Melanoma..

01 Jan 2021

Kirkwood J, Dummer R, Hauschild A, Santinami M, Atkinson V, Sileni V, Larkin J, Nyakas M, Haydon A, Dutriaux C, Schachter J, Robert C, Mortier L, Banerjee H, Haas T, Tan M, Lau M, Schadendorf D, Long G, Mandala M.  SKIN The Journal of Cutaneous Medicine 5, no. 1 (Epub Jan 1 2021)